Wednesday, May 14, 2014

Dealing with Irreproducibility

Recent years have seen increasing numbers of retractions, higher rates of misconduct and fraud, and general problems of data irreproducibility, spurring the National Institutes of Health (NIH) and others to launch initiatives to improve the quality of research results...“We really have to change our culture and that will not be easy,” said Lee Ellis from the University of Texas MD Anderson Cancer Center, referring to the immense pressure researchers often feel to produce splashy results and publish in high-impact journals...C. Glenn Begley, chief scientific officer of TetraLogic Pharmaceuticals and former vice president of hematology and oncology research at Amgen, discussed a project undertaken by Amgen researchers to reproduce the results of more than 50 published studies. The vast majority were irreproducible, even by the original researchers who had done the work. “That shocked me,” he said. more

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